Health, Medical Advice

Oxycodone Vs Morphine: Which PainKiller Is Better?

Oxycodone Vs Morphine

Oxycodone and Morphine are the two medicines, which are used to treat cancer-related pain in patients. Both drugs treat their problems in different ways. They are made up of several ingredients for the treatment of moderate-to-severe pain. These medicines are generic drugs. They are used for the treatment of severe pain, which occurs due to several problems in people. Although both medicines are used to relieve pain, they are prescribed differently. Here in this article ‘Oxycodone Vs Morphine’, you can get detailed information on both medicines.

This blog is all about the comparison between the two medicines, which include Oxycodone and Morphine.

What is Oxycodone Medicine?

Oxycodone is a medicine, that treats moderate-to-severe pain in patients. People use this medicine for the treatment of cancer and other problems as well. It contains an active ingredient called Oxycodone Hydrochloride. The molar mass of Oxycodone medicine is 351.83 g/mol.

Properties of Oxycodone Medicine

The physical properties of Oxycodone medicine are as follows:

  • It is soluble in ethanol and chloroform, but insoluble in potassium hydroxide, sodium hydroxide, ether, and water.
  • It has a melting point of 219 degrees Celsius.
  • The refractive index of Oxycodone medicine is 1.66.

What is Morphine Medicine?

Morphine is a medicine, which is used for the treatment of intense problems. It is used by people, who experience severe pain in the body. The active ingredients of Morphine medicine are Morphine-3-Glucuronide (M3G) and Morphine-6-Glucuronide (M6G). The molar mass of this medicine is 285.34 g/mol.

Properties of Morphine Medicine

There are different physical properties of Morphine medicine. These include the following:

  • Morphine medicine has a melting and boiling point of 255 degrees Celsius and 190 degrees Celsius, respectively.
  • The density of Morphine medicine is 1.32 g/ml.
  • It is soluble in water.
  • It is a white crystalline medicine.

Comparison: Oxycodone Vs Morphine Medicines

Below are several comparisons between Oxycodone and Morphine medicines. These are as follows:

  • Food and Drug Administration (FDA) approval
  • Both medicines have obtained Food and Drug Administration (FDA) approval in different years.

Read the following information about the FDA approval of Oxycodone and Morphine medicines.

  • Oxycodone: Oxycodone medicine was first approved by the Food and Drug Administration (FDA) in the year 1998.
  • Morphine: The Food and Drug Administration (FDA) approved Morphine medicine in the year 1987.

Brand Names

The brand names of Oxycodone and Morphine medicines are given below:

  • Oxycodone: The brand names of Oxycodone medicine are Oxaydo, Roxicodone, Dazidox, Roxybond, Endocodone, Oxydose, Oxyfast, ETH-Oxydose and Xtampza ER.
  • Morphine: There are different brand names of Morphine medicine available in the market. These include Infumorph, Duramorph, Arymo ER, Depodur, Kadian, MorphaBond, Astramorph and MS Contin.

Dosages Strengths & Forms

Each drug consists of different dosages depending upon their strengths and forms. Read the following brief information about the dosages of Oxycodone and Morphine medicine:

  • Oxycodone: Oxycodone medicine consists of several dosages to treat severe pain in adults and children. They are available in the forms of extended-release oral tablets, oral tablets, oral capsules, oral solutions, and oral concentrates.
    • The dosage strengths of Oxycodone are 1mg/ml oral solution, 20mg/ml oral concentration, 5mg oral capsule, 5mg, 7.5mg, 20mg, 30mg, 15mg, and 10mg extended-release oral tablets.
  • Morphine: Morphine medicine is available in different forms for the treatment of adults and children. These include oral solutions, oral tablets, oral concentrate, extended-release oral tablets, and capsules.
    • Morphine medicine consists of several dosage strengths. These include 20mg/ml oral concentrate, 20mg/ml, 4mg/ml, and 2mg/ml oral solution, and 15mg and 30mg oral tablets. The dosage strengths of extended-release oral capsules are 80mg, 90mg, 30mg, 50mg, 60mg, 45mg, 10mg, 20mg, 100mg, and 120mg, whereas the dosage strengths of extended-release oral tablets are 15mg, 60mg, 200mg, 30mg, and 100mg.


The functions of both medicines are different, but the main purpose is to reduce pain signals in people. Brief information about the function of Oxycodone and Morphine medicines is given below:

  • Oxycodone: The function of Oxycodone is to block pain signals in the central part of the nervous system, which reduces several problems in people. These include fatigue, anxiety, sleeping problems, etc.
  • Morphine: Morphine reduces the signals of the nerve pain between the brain and the body. It works directly on opioid receptors in the central part of the nervous system.

Half-Life & Drug Interactions

The half-life of Oxycodone medicine is 5.6 hours, whereas Morphine medicine has a half-life of 4 hours.

Both medicines can interact with several medicinal drugs. Read the following drug interactions of Oxycodone and Morphine medicine:

  • Oxycodone: 583 medicinal drugs can interact with Oxycodone medicine, these include 1 small, 372 medium, and 210 large drugs. They are Evening Primrose, Bosentan, Conivaptan, Haloperiodal, Pentazocine, Zolpidem, Sodium Oxybate, Rasagiline, Quetiapine, Osilodrostat, Pyrilamine, Opicapone etc.
  • Morphine: Morphine medicine can interact with 534 medicinal drugs, these consist of 14 small, 321 medium, and 199 large drugs. They include Yohimbine, Ephedrine, Cisapride, Drospirenone, Levonorgestrel, Benzthiazide, Brompheniramine, Polythiazide, Sodium Polystyrene Sulfonate, Ulipristal, Esketamine, Ramelteon, Voclosporin, Tizanidine etc.

Side Effects

Oxycodone and Morphine drugs cause severe and common side effects in individuals because of their prolonged use. They also cause other problems in patients. Read the following to know the side effects of Oxycodone and Morphine medicines.


There are several side effects of Oxycodone medicine, which include the following:

  • Light-headedness
  • Stomach pain
  • Dryness in mouth
  • Swallowing problems
  • Wrinkles
  • Skin redness or rashes
  • Muscle pain
  • Chest pain
  • Seizures
  • Increase in the rate of heartbeat
  • Quick weight gain


Morphine medicine causes different side effects in people. These are as follows:

  • Diarrhea
  • Dizziness
  • Drowsiness
  • Skin discoloration
  • Breathing problems
  • Twitching
  • Sweating
  • Shivering
  • Fever
  • Urine problem
  • Agitation


This blog explains the comparison between Oxycodone and Morphine medicine (Oxycodone vs Morphine). They consist of different dosages and ingredients to treat severe pain in individual patients.

However, Oxycodone and Morphine medicines also cause different side effects in people. Individuals must consult with a doctor before taking these medicines.

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