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Hydrocodone is an opioid pain medication. The primary purpose of this medication is for the treatment of severe pain. Hydrocodone is only prescribed to people who are expected to require medication to get relief from severe pain around the clock for an extended period and who are unable to be treated with other medications or treatments. The effectiveness and demand of Hydrocodone allow it to be available online making it easy for customers to buy Hydrocodone online.

The two extended-release forms of Hydrocodone Zohydro ER and Hysingla ER that are mainly used for the around-the-clock treatment of severe pain. Hydrocodone extended-release (long-acting) capsules or extended-release tablets should only be used if other medicines do not work.

Hydrocodone has been approved by the Food and Drug Administration (FDA) as an opioid analgesic to treat ever-occurring pain on a daily basis. It is used as long-term opioid treatment and for which alternative treatment options are inadequate.

It is an essential component present in various branded medicines such as Zohydro ER and Hysingla ER. This drug comes under the class of medications called opiate (narcotic) analgesics.

Comparing the Mechanism of Action and Effectiveness:

Action and efficacy are the main elements of medicine, especially in the case of buying online. So, here we are providing you simplified details for the mode of action and efficacy of Hydrocodone. It will help you understand the action mechanism and effectiveness before buying Hydrocodone drugs online or offline.

Mechanism of Action:

The opioid analgesic hydrocodone works by binding opioid receptors in the central nervous system (CNS). These receptors are found in areas of the brain and spinal cord that are involved in the perception of pain. When hydrocodone binds these receptors, it prevents pain signals from reaching the brain and thus reduces pain perception.

Hydrocodone primarily binds mu-opioid receptors, but it also binds delta and kappa opioid receptors. The analgesic effects of hydrocodone are mediated by mu-opioid receptors, whereas delta- and kappa-opioid receptors may contribute to other effects such as sedation, respiratory complications, and constipation.

Hydrocodone is metabolized in the liver and excreted through the urine and feces. The half-life of hydrocodone is about 4 hours, meaning that it takes about 4 hours for half of the drug’s effect to be eliminated from the body.

Effectiveness of Hydrocodone:

Hydrocodone is a semi-synthetic opioid pain reliever that works well for moderate to severe pain. It is frequently used to treat pain caused by surgery, cancer, or trauma. Hydrocodone is also effective in treating cough.

The effectiveness of this medication varies according to the type and severity of pain. Hydrocodone is typically as or more effective than other opioid pain medications, such as morphine or oxycodone, for healing moderate to severe pain.

Hydrocodone is often more effective than Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as ibuprofen or naproxen for mild pain. Effects of Hydrocodone can be experienced usually within 10 to 30 minutes after taken orally. Hydrocodone IR stays active for 6-8 hours, while the effects of ER last longer than IR.

Uses and Doses for maximum Hydrocodone benefit:

When you buy Hydrocodone online its uses and doses are the must-know features. Take a look to learn more about the uses and doses of Hydrocodone.


Hydrocodone is typically recommended for the treatment of moderate to severe pain. It is an opioid medication that is generally used for all kinds of complications that occur due to pain. Whereas, this narcotic analgesia is also used for treating cough. The liquid formulation of Hydrocodone is mostly preferred for healing cough.

Zohydro ER and Hysingla ER are considered the extended-release forms of Hydrocodone that are used for around-the-clock treatment of severe pain.

Keep in mind that Hydrocodone can be habit-forming. Slow or harsh trouble in breathing may occur even at regular doses. It is necessary to follow all the directions and read all medication guides available on the prescription label.


Hydrocodone is a generic name for two brands known as Zohydro ER and Hysingla ER. Both the branded medicines are classified as Controlled Substance Schedule II category (CII).

Zohydro ER is available in the form of an oral capsule. On the other hand, Hysingla ER is available in the form of an oral tablet.

The dosage form and strengths are included below:

Zohydro Extended-Release (ER) Capsule: 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, and 50 mg.

Hysingla Extended-Release (ER) Tablet: 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, 100 mg and 120 mg.

The optimal dosage of Zohydro ER and Hysingla ER for patients who are not opioid tolerant is 10 mg and is taken orally every 12 hours and 20 mg every 24 hours, respectively.

Working – Function of Hydrocodone:

Hydrocodone functions as a semi-synthetic opioid that binds mu-opioid receptors (MOR) in the central nervous system.

It is believed to work by activating opioid receptors, which are found primarily in the brain and spinal cord. Hydrocodone is mainly an agonist of mu-opioid receptors, but it is also a weak agonist of delta and kappa opioid receptors.

The agonist effect of hydrocodone at the MOR is thought to be the most important contributor due to its analgesic effects. The primary therapeutic action of Hydrocodone is analgesia.

Potential Side Effects and Risks of  Hydrocodone:

It is important to be aware of the potential side effects and risks associated with Hydrocodone before purchasing it online. The opioid pain medication is used to treat moderate to severe pain. However, it also has a number of potential side effects, which are listed below.

Side Effects:

  • Constipation
  • Nausea
  • Vomiting
  • Dizziness
  • Drowsiness
  • Feeling tired (fatigue)
  • Headache
  • Stuffy nose
  • Sore throat
  • Sneezing


  • Slow heart rate
  • Difficulty in breathing
  • Pain while urinating
  • Tremors
  • Burning sensation when urinating
  • Light-headed feeling
  • Confusion
  • Severe drowsiness
  • Weakness in body
  • Death

Steps to Buy Hydrocodone Online:

First search for a trusted and genuine online pharmacy with reasonable prices. Then check the reviews or delivery proof of the pharmacy. Once you are convinced, you can place your order. Make sure to overcheck the back of the medicine with your medical guide to sure that the medicine is genuine.

Alternatives to Hydrocodone:

The secondary option is the common mindset for every person, mainly at the time of buying medicines online. Don’t worry we’re providing you with a list of some common alternatives to Hydrocodone.

  • Belbuca (Buprenorphine) – The brand name of Buprenorphine is Belbuca. Buprenorphine is an active ingredient of Belbuca that is approved for chronic pain. As both are partial agonists at mu-opioid receptors, however, the mode of action of Buprenorphine differs from Hydrocodone.
  • Methadose – Methadose is an option for patients with chronic pain as an alternative to hydrocodone. It may be a viable option when side effects have limited ability, as well as in cases of opioid-induced hyperalgesia.
  • Cymbalta (Duloxetine) – Cymbalta is an effective alternative pain reliever to Lortab, which is another pain reliever that is used for the management of certain chronic pain. Cymbalta is a non-opioid medication and was originally labeled as an antidepressant.
  • Naprosyn (Naproxen) – Naprosyn is a type of NSAID. According to several clinical scenarios, this medication may serve as a good alternative to opioid drugs like Hydrocodone.
  • Tramadol (Qdolo) – In some patients, Qdolo (Tramadol) can be used instead of stronger opioids. It is a synthetic codeine analog, a weak mu-opioid receptor agonist, and a weak Serotonin and Norepinephrine Reuptake Inhibitors (SNRI).